Role of HIV-specific CD8(+) T cells in pediatric HIV cure strategies after widespread early viral escape.
Identifieur interne : 000278 ( Main/Exploration ); précédent : 000277; suivant : 000279Role of HIV-specific CD8(+) T cells in pediatric HIV cure strategies after widespread early viral escape.
Auteurs : Ellen M. Leitman [Royaume-Uni] ; Christina F. Thobakgale [Afrique du Sud] ; Emily Adland [Royaume-Uni] ; M Azim Ansari [Royaume-Uni] ; Jayna Raghwani [Royaume-Uni] ; Andrew J. Prendergast [Royaume-Uni] ; Gareth Tudor-Williams [Royaume-Uni] ; Photini Kiepiela [Afrique du Sud] ; Joris Hemelaar [Royaume-Uni] ; Jacqui Brener [Royaume-Uni] ; Ming-Han Tsai [Royaume-Uni] ; Masahiko Mori [Royaume-Uni] ; Lynn Riddell [Royaume-Uni] ; Graz Luzzi [Royaume-Uni] ; Pieter Jooste [Afrique du Sud] ; Thumbi Ndung'U [Afrique du Sud] ; Bruce D. Walker [Afrique du Sud] ; Oliver G. Pybus [Royaume-Uni] ; Paul Kellam [Royaume-Uni] ; Vivek Naranbhai [États-Unis] ; Philippa C. Matthews [Royaume-Uni] ; Astrid Gall [Royaume-Uni] ; Philip J R. Goulder [Royaume-Uni]Source :
- The Journal of experimental medicine [ 1540-9538 ] ; 2017.
Abstract
Recent studies have suggested greater HIV cure potential among infected children than adults. A major obstacle to HIV eradication in adults is that the viral reservoir is largely comprised of HIV-specific cytotoxic T lymphocyte (CTL) escape variants. We here evaluate the potential for CTL in HIV-infected slow-progressor children to play an effective role in "shock-and-kill" cure strategies. Two distinct subgroups of children were identified on the basis of viral load. Unexpectedly, in both groups, as in adults, HIV-specific CTL drove the selection of escape variants across a range of epitopes within the first weeks of infection. However, in HIV-infected children, but not adults, de novo autologous variant-specific CTL responses were generated, enabling the pediatric immune system to "corner" the virus. Thus, even when escape variants are selected in early infection, the capacity in children to generate variant-specific anti-HIV CTL responses maintains the potential for CTL to contribute to effective shock-and-kill cure strategies in pediatric HIV infection.
DOI: 10.1084/jem.20162123
PubMed: 28983013
Affiliations:
- Afrique du Sud, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Massachusetts, Oxfordshire
- Londres, Oxford
- Université d'Oxford, Université de Londres
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Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea><wicri:noRegion>Durban</wicri:noRegion></affiliation></author><author><name sortKey="Walker, Bruce D" sort="Walker, Bruce D" uniqKey="Walker B" first="Bruce D" last="Walker">Bruce D. 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Pybus</name><affiliation wicri:level="4"><nlm:affiliation>Department of Zoology, University of Oxford, Oxford, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Zoology, University of Oxford, Oxford, England</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Kellam, Paul" sort="Kellam, Paul" uniqKey="Kellam P" first="Paul" last="Kellam">Paul Kellam</name><affiliation wicri:level="1"><nlm:affiliation>Kymab Ltd., Babraham Research Campus, Babraham, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kymab Ltd., Babraham Research Campus, Babraham, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Naranbhai, Vivek" sort="Naranbhai, Vivek" uniqKey="Naranbhai V" first="Vivek" last="Naranbhai">Vivek Naranbhai</name><affiliation wicri:level="2"><nlm:affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Matthews, Philippa C" sort="Matthews, Philippa C" uniqKey="Matthews P" first="Philippa C" last="Matthews">Philippa C. 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Leitman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Paediatrics, University of Oxford, Oxford, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatrics, University of Oxford, Oxford, England</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Thobakgale, Christina F" sort="Thobakgale, Christina F" uniqKey="Thobakgale C" first="Christina F" last="Thobakgale">Christina F. Thobakgale</name><affiliation wicri:level="1"><nlm:affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea><wicri:noRegion>Durban</wicri:noRegion></affiliation></author><author><name sortKey="Adland, Emily" sort="Adland, Emily" uniqKey="Adland E" first="Emily" last="Adland">Emily Adland</name><affiliation wicri:level="4"><nlm:affiliation>Department of Paediatrics, University of Oxford, Oxford, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatrics, University of Oxford, Oxford, England</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Ansari, M Azim" sort="Ansari, M Azim" uniqKey="Ansari M" first="M Azim" last="Ansari">M Azim Ansari</name><affiliation wicri:level="4"><nlm:affiliation>Oxford Martin School, University of Oxford, Oxford, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Martin School, University of Oxford, Oxford, England</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Raghwani, Jayna" sort="Raghwani, Jayna" uniqKey="Raghwani J" first="Jayna" last="Raghwani">Jayna Raghwani</name><affiliation wicri:level="4"><nlm:affiliation>Department of Zoology, University of Oxford, Oxford, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Zoology, University of Oxford, Oxford, England</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Prendergast, Andrew J" sort="Prendergast, Andrew J" uniqKey="Prendergast A" first="Andrew J" last="Prendergast">Andrew J. Prendergast</name><affiliation wicri:level="4"><nlm:affiliation>Blizard Institute, Queen Mary University of London, London, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Queen Mary University of London, London, England</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Tudor Williams, Gareth" sort="Tudor Williams, Gareth" uniqKey="Tudor Williams G" first="Gareth" last="Tudor-Williams">Gareth Tudor-Williams</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medicine, Department of Paediatrics, Imperial College London, London, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Medicine, Department of Paediatrics, Imperial College London, London, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Kiepiela, Photini" sort="Kiepiela, Photini" uniqKey="Kiepiela P" first="Photini" last="Kiepiela">Photini Kiepiela</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Medical Research Council, Durban</wicri:regionArea><wicri:noRegion>Durban</wicri:noRegion></affiliation></author><author><name sortKey="Hemelaar, Joris" sort="Hemelaar, Joris" uniqKey="Hemelaar J" first="Joris" last="Hemelaar">Joris Hemelaar</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, England</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Brener, Jacqui" sort="Brener, Jacqui" uniqKey="Brener J" first="Jacqui" last="Brener">Jacqui Brener</name><affiliation wicri:level="4"><nlm:affiliation>Department of Paediatrics, University of Oxford, Oxford, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatrics, University of Oxford, Oxford, England</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Tsai, Ming Han" sort="Tsai, Ming Han" uniqKey="Tsai M" first="Ming-Han" last="Tsai">Ming-Han Tsai</name><affiliation wicri:level="4"><nlm:affiliation>Department of Paediatrics, University of Oxford, Oxford, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatrics, University of Oxford, Oxford, England</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Mori, Masahiko" sort="Mori, Masahiko" uniqKey="Mori M" first="Masahiko" last="Mori">Masahiko Mori</name><affiliation wicri:level="4"><nlm:affiliation>Department of Paediatrics, University of Oxford, Oxford, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatrics, University of Oxford, Oxford, England</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Riddell, Lynn" sort="Riddell, Lynn" uniqKey="Riddell L" first="Lynn" last="Riddell">Lynn Riddell</name><affiliation wicri:level="1"><nlm:affiliation>Northampton Healthcare NHS Foundation Trust, Cliftonville, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Northampton Healthcare NHS Foundation Trust, Cliftonville, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Luzzi, Graz" sort="Luzzi, Graz" uniqKey="Luzzi G" first="Graz" last="Luzzi">Graz Luzzi</name><affiliation wicri:level="1"><nlm:affiliation>Buckinghampshire Healthcare NHS Foundation Trust, High Wycombe, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Buckinghampshire Healthcare NHS Foundation Trust, High Wycombe, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Jooste, Pieter" sort="Jooste, Pieter" uniqKey="Jooste P" first="Pieter" last="Jooste">Pieter Jooste</name><affiliation wicri:level="1"><nlm:affiliation>Paediatric Department, Kimberley Hospital, Northern Cape, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Paediatric Department, Kimberley Hospital, Northern Cape</wicri:regionArea><wicri:noRegion>Northern Cape</wicri:noRegion></affiliation></author><author><name sortKey="Ndung U, Thumbi" sort="Ndung U, Thumbi" uniqKey="Ndung U T" first="Thumbi" last="Ndung'U">Thumbi Ndung'U</name><affiliation wicri:level="1"><nlm:affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea><wicri:noRegion>Durban</wicri:noRegion></affiliation></author><author><name sortKey="Walker, Bruce D" sort="Walker, Bruce D" uniqKey="Walker B" first="Bruce D" last="Walker">Bruce D. Walker</name><affiliation wicri:level="1"><nlm:affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea><wicri:noRegion>Durban</wicri:noRegion></affiliation></author><author><name sortKey="Pybus, Oliver G" sort="Pybus, Oliver G" uniqKey="Pybus O" first="Oliver G" last="Pybus">Oliver G. Pybus</name><affiliation wicri:level="4"><nlm:affiliation>Department of Zoology, University of Oxford, Oxford, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Zoology, University of Oxford, Oxford, England</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Kellam, Paul" sort="Kellam, Paul" uniqKey="Kellam P" first="Paul" last="Kellam">Paul Kellam</name><affiliation wicri:level="1"><nlm:affiliation>Kymab Ltd., Babraham Research Campus, Babraham, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kymab Ltd., Babraham Research Campus, Babraham, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Naranbhai, Vivek" sort="Naranbhai, Vivek" uniqKey="Naranbhai V" first="Vivek" last="Naranbhai">Vivek Naranbhai</name><affiliation wicri:level="2"><nlm:affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Matthews, Philippa C" sort="Matthews, Philippa C" uniqKey="Matthews P" first="Philippa C" last="Matthews">Philippa C. Matthews</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Oxford, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Oxford, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Gall, Astrid" sort="Gall, Astrid" uniqKey="Gall A" first="Astrid" last="Gall">Astrid Gall</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Goulder, Philip J R" sort="Goulder, Philip J R" uniqKey="Goulder P" first="Philip J R" last="Goulder">Philip J R. Goulder</name><affiliation wicri:level="4"><nlm:affiliation>Department of Paediatrics, University of Oxford, Oxford, England, UK philip.goulder@paediatrics.ox.ac.uk.</nlm:affiliation><country wicri:rule="url">Royaume-Uni</country><wicri:regionArea>Department of Paediatrics, University of Oxford, Oxford, England</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of experimental medicine</title><idno type="eISSN">1540-9538</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent studies have suggested greater HIV cure potential among infected children than adults. A major obstacle to HIV eradication in adults is that the viral reservoir is largely comprised of HIV-specific cytotoxic T lymphocyte (CTL) escape variants. We here evaluate the potential for CTL in HIV-infected slow-progressor children to play an effective role in "shock-and-kill" cure strategies. Two distinct subgroups of children were identified on the basis of viral load. Unexpectedly, in both groups, as in adults, HIV-specific CTL drove the selection of escape variants across a range of epitopes within the first weeks of infection. However, in HIV-infected children, but not adults, de novo autologous variant-specific CTL responses were generated, enabling the pediatric immune system to "corner" the virus. Thus, even when escape variants are selected in early infection, the capacity in children to generate variant-specific anti-HIV CTL responses maintains the potential for CTL to contribute to effective shock-and-kill cure strategies in pediatric HIV infection.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Massachusetts</li><li>Oxfordshire</li></region><settlement><li>Londres</li><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Leitman, Ellen M" sort="Leitman, Ellen M" uniqKey="Leitman E" first="Ellen M" last="Leitman">Ellen M. Leitman</name></region><name sortKey="Adland, Emily" sort="Adland, Emily" uniqKey="Adland E" first="Emily" last="Adland">Emily Adland</name><name sortKey="Ansari, M Azim" sort="Ansari, M Azim" uniqKey="Ansari M" first="M Azim" last="Ansari">M Azim Ansari</name><name sortKey="Brener, Jacqui" sort="Brener, Jacqui" uniqKey="Brener J" first="Jacqui" last="Brener">Jacqui Brener</name><name sortKey="Gall, Astrid" sort="Gall, Astrid" uniqKey="Gall A" first="Astrid" last="Gall">Astrid Gall</name><name sortKey="Goulder, Philip J R" sort="Goulder, Philip J R" uniqKey="Goulder P" first="Philip J R" last="Goulder">Philip J R. Goulder</name><name sortKey="Hemelaar, Joris" sort="Hemelaar, Joris" uniqKey="Hemelaar J" first="Joris" last="Hemelaar">Joris Hemelaar</name><name sortKey="Kellam, Paul" sort="Kellam, Paul" uniqKey="Kellam P" first="Paul" last="Kellam">Paul Kellam</name><name sortKey="Luzzi, Graz" sort="Luzzi, Graz" uniqKey="Luzzi G" first="Graz" last="Luzzi">Graz Luzzi</name><name sortKey="Matthews, Philippa C" sort="Matthews, Philippa C" uniqKey="Matthews P" first="Philippa C" last="Matthews">Philippa C. Matthews</name><name sortKey="Mori, Masahiko" sort="Mori, Masahiko" uniqKey="Mori M" first="Masahiko" last="Mori">Masahiko Mori</name><name sortKey="Prendergast, Andrew J" sort="Prendergast, Andrew J" uniqKey="Prendergast A" first="Andrew J" last="Prendergast">Andrew J. Prendergast</name><name sortKey="Pybus, Oliver G" sort="Pybus, Oliver G" uniqKey="Pybus O" first="Oliver G" last="Pybus">Oliver G. Pybus</name><name sortKey="Raghwani, Jayna" sort="Raghwani, Jayna" uniqKey="Raghwani J" first="Jayna" last="Raghwani">Jayna Raghwani</name><name sortKey="Riddell, Lynn" sort="Riddell, Lynn" uniqKey="Riddell L" first="Lynn" last="Riddell">Lynn Riddell</name><name sortKey="Tsai, Ming Han" sort="Tsai, Ming Han" uniqKey="Tsai M" first="Ming-Han" last="Tsai">Ming-Han Tsai</name><name sortKey="Tudor Williams, Gareth" sort="Tudor Williams, Gareth" uniqKey="Tudor Williams G" first="Gareth" last="Tudor-Williams">Gareth Tudor-Williams</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Thobakgale, Christina F" sort="Thobakgale, Christina F" uniqKey="Thobakgale C" first="Christina F" last="Thobakgale">Christina F. Thobakgale</name></noRegion><name sortKey="Jooste, Pieter" sort="Jooste, Pieter" uniqKey="Jooste P" first="Pieter" last="Jooste">Pieter Jooste</name><name sortKey="Kiepiela, Photini" sort="Kiepiela, Photini" uniqKey="Kiepiela P" first="Photini" last="Kiepiela">Photini Kiepiela</name><name sortKey="Ndung U, Thumbi" sort="Ndung U, Thumbi" uniqKey="Ndung U T" first="Thumbi" last="Ndung'U">Thumbi Ndung'U</name><name sortKey="Walker, Bruce D" sort="Walker, Bruce D" uniqKey="Walker B" first="Bruce D" last="Walker">Bruce D. Walker</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Naranbhai, Vivek" sort="Naranbhai, Vivek" uniqKey="Naranbhai V" first="Vivek" last="Naranbhai">Vivek Naranbhai</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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